Journal article
Impact of Reticular Pseudodrusen on Choriocapillaris Flow Deficits and Choroidal Structure on Optical Coherence Tomography Angiography
Z Wu, X Zhou, Z Chu, G Gregori, RK Wang, PJ Rosenfeld, RH Guymer
Investigative Ophthalmology and Visual Science | ASSOC RESEARCH VISION OPHTHALMOLOGY INC | Published : 2022
DOI: 10.1167/iovs.63.12.1
Abstract
PURPOSE. To examine the impact of reticular pseudodrusen (RPD) on choriocapillaris blood flow and choroidal structure in individuals with intermediate age-related macular degeneration (AMD). METHODS. Individuals with bilateral large drusen underwent optical coherence tomography (OCT), color fundus photography, near-infrared reflectance, and fundus autofluorescence imaging to determine the presence of RPD. These participants also underwent swept-source OCT angiography (SS-OCTA) imaging to determine (1) choriocapillaris flow deficit (FD) parameters, including the percentage, mean size, and number of FDs present; and (2) choroidal structural parameters, including mean choroidal thickness and ch..
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Grants
Awarded by Research to Prevent Blindness
Funding Acknowledgements
Supported by research fellowships from the National Health & Medical Research Council of Australia (GNT1103013 to RHG, GNT1194667 to RHG, APP1104985 to ZW, 2008382 to ZW) ; by a grant from the National Health & Medical Research Council of Australia (GNT1181010 to RHG and ZW) ; by a grant from the Macular Disease Foundation Australia (ZW and RHG) ; by a Center Core Grant from the National Eye Institute, National Institutes of Health (P30EY014801 to PJR and GG) ; and by a Research to Prevent Blindness unrestricted grant to the Department of Ophthalmology, Miller School of Medicine, University of Miami. Carl Zeiss Meditec provided the PLEX Elite 9000 instru-ment and technical support via the ARI Network. The Centre for Eye Research Australia receives operational infrastructure support from the Victorian Government.